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Currently available immunoglobulin products and their properties Dosage formulation Refrigeration Filtration required Prompt diagnosis and treatment of these events are required to ensure patient safety. Many of the newer products have eliminated sugars as stabilizing agents and have substituted amino acids to eliminate this potential risk for renal compromise. An association with neurodegeneration has been reported; however, a mechanism is currently unknown. The investigators ultimately recommended dosage based on measured serum IgG levels and the clinical response instead of mean pharmacokinetic parameters. Typical sites of infusion include the abdomen, outer thigh, upper arm, and buttock. The number of sites will depend on the number needed to provide the total volume for the calculated target dose. Thus, dosage reductions in general should be approached with great caution, and there is no prescribed or proven protocol for a step-down approach to find the minimal dose of immunoglobulin replacement therapy required for keeping a patient infection-free. This benefit results in greater patient satisfaction and fewer missed days of work or school for infusion-clinic appointments. Providers must be able to offer adequate education, training, and support for patients. As immunoglobulin has diverse therapeutic mechanisms of action, the list of indications in which it is useful is likely to grow. Given the limited nature of this therapeutic agent, careful consideration of particular clinical indications is of the essence. Our recommendations do not relate to the severity of these particular diseases or to the potential for alternative therapies to be effective. Immunoglobulin therapy should be applied where it is most supported by evidence and where it will provide the greatest clinical benefit. The evidence considered in this document, as well as the recommendations based therein, should be viewed as currently relevant but likely to change given ongoing research and cumulative experience. Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature. Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma & Immunology. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society-first revision. Subcutaneous immunoglobulin therapy for the treatment of multifocal motor neuropathy: a case report. Subcutaneous immunoglobulin in polymyositis and dermatomyositis: a novel application. Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. Use of intravenous gamma-globulin in antibody immunodeficiency: results of a multicenter controlled trial. Controversies in IgG replacement therapy in patients with antibody deficiency diseases. Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients. High- vs low-dose immunoglobulin therapy in the long-term treatment of X-linked agammaglobulinemia. Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies. B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review. Efficacy of intravenous immunoglobulin in primary humoral immunodeficiency disease. Benefit of intravenous IgG replacement in hypogammaglobulinemic patients with chronic sinopulmonary disease. Common variable immunodeficiency: clinical and immunological features of 248 patients. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency.

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Florida "A Genetic Screen in Zebrafish Identifies Genes Required for Liver Development" Kirsten Sadler, Ph. D, Harvard University "Assembly and Function of Visual Channels in Zebrafish" Herwig Baier, Ph. Pittsburgh School of Medicine Seventh Annual Intensive Course in Quantitative Fluorescent Microscopy Simon Watkins, PhD, U. Adult neurogenesis in the crustacean brain: comparative cell cycle dynamics and regulatory controls. The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste. Critical salinity, sensitivity, and commitment to salinity-mediated carbonic anhydrase induction in the gills of two euryhaline species of decapod crustaceans. Permeabilities of teleost and elasmobranch gill apical membranes: evidence that lipid bilayers alone do not account for barrier function. Effect of cortisol on aquaporin expression in the oesophagus of the European eel, Anguilla anguilla. Regulation of expression of two aquaporin homologues in the intestine of the European eel: effects of seawater acclimation and cortisol treatment. Tyrosine kinase inhibition affects skate anion exchanger isoform 1 alteration after volume expansion. Stimulation of renal sulfate secretion by metabolic acidosis requires Na+/H+ exchange induction and carbonic anhydrase. Photoreceptive systems in crustaceans and the entertainment of rhythmic adult neurogenesis. Gene expression after freshwater transfer in gills and opercular epithelia of killifish: insight into divergent mechanisms of ion transport. Ballatori, Ned Barnaby, Roxanna Barnes, David Bayne, Christopher Belmonte, Steve Beltz, Barbara Beltz, Eleanor Benton, Jeannie Boehme, Lisa Boyer, James L. Bradley, Marianna Burdick, Daniel Butterworth, Michael Cai, Shi-Ying Chapline, Christine Cheruvu, Pavan Cheung, David Childers, Jason Choe, Keith P. Crockett, Elizabeth Cutler, Christopher Czechanski, Anne Da Cuna, Rodrigo Daniels, Jessica Davis, Allan P. De Berge, Matthew Decker, Sarah Deshpande, Ashok 88 87 52, 129 25 45 47, 50, 137 125 60, 119 60 25 91, 104, 112 20 104 76 47, 50, 137, 139 12 112 23 47, 50, 137 17 88 60 12 33, 35, 44, 66, 68, 70 49, 113 25, 29 78 52, 129 121 121 107 40, 42, 109 60 127 126 139 126 29 12 19, 20, 23 133 Diamanduros, Andrew W. Frederich, Markus Fricker, Gert Frizzell, Raymond Gabor, Kristin Gale, Daniel Galardi-Este, Oriana Gaskins, H. Rex Genovese, Griselda Goldstein, Leon Gutmann, Heike Haller, Hermann Hamilton, Joshua Hamilton, Rebecca Hand, Emily Harmel, Nadine Hartline, Daniel Hassett, R. Holt, Shawn Janowski, Einsley Jillette, Nathaniel Jones, Linda Kapinova, Eda Karim, Zachary S. Lalemand, Laura Lanier, Curtis Lee, Jim Young Liebsch, Fabian Long, Jeremy Long, John H. Luchini, Gina Luquet, Carlos MacIver, Bruce Maggese, Cristina Maltz, Erica Martyanov, Igor N. Bailey Mitchell, Elizabeth Morad, Martin Motley, William 117 133 109 58 29 74 126 58 109 17, 125 126 19 12, 45, 101 29 1, 87 121 63, 78 78 29 35, 66, 68, 70 101 82, 84, 97 49 29, 137 76 69 63, 78 74 49 99, 127 109 127 12 121 52, 129, 139 101 91 11 47, 124, 126 107 112 25, 29 20 Movafagh, Shahrzad Musch, Mark Nagase, Hiroko Nava, Gerardo M. Sighinolfi, Christopher Silva, Patricio Sircar, Suravi Song, Linhua Smith, Noah W. Swenson, Kai Telles, Connor 29 11 29 52, 129 137 37 129 16 60, 119 17 20 12, 45, 101 133 25 20, 23 12, 45, 101 11 19 127 117 29 139 47 17 91, 104 17, 125 63 76 71 47 125 95 82, 84, 95, 97 58 63 52 25 82, 84, 95, 97 17, 125 125 44 133 126 20 Thibodeau, Renee Tlusty, Michael Tomana, Mitsuru Tully, Stephanie Towle, David Villalobos, Alice R. American rainbow crab) Strongylocentrotus droebachiensis (green sea urchin) Ciona intestinalis (sea vase) Strongylocentrotus purpuratus (purple sea urchin) Danio rerio (zebrafish) Xenopus laevis (African clawed frog) Fucus vesiculosus (bladder wrack) Fundulus heteroclitus (killifish) Homarus americanus (American lobster) Idotea baltica (isopod) Laminaria sp. Maren Foundation University of Florida Scholars Program Universidad de Buenos Aires University of Hawaii Woodcock Foundation 25, 29 15, 16, 19, 20, 23, 50, 53, 109, 137 125, 139 17, 19, 20, 23, 50, 52, 87, 125, 126, 129, 133 60 107 78 44, 70, 74, 126 33, 35 127 112 119. Some categories have additional information to further specify a subgroup of patients for whom the category was assigned. This section lists the number of patients reported in the literature who were treated with therapeutic apheresis. The number of randomized controlled trials and the total number of patients studied. For example, 4(250) indicates that there were four randomized controlled trials with 250 enrolled patients. The minimum requirement for these studies was randomization to a control arm and a test arm.

In many cases, suicide can be prevented through the early recognition and treatment of mental disorders. At least 90 percent of all people who die by suicide have a mental or substance abuse disorder, or a combination of disorders (5). However, most persons with a mental or substance abuse disorder do not kill themselves; thus other factors contribute to suicide risk. Additional risk factors include prior suicide attempts, stressful life events, access to lethal suicide methods, family history of suicide, and family history of mental disorder or substance abuse (14). Due to the difficulty in predicting suicide, prevention efforts focus on these risk factors. Thus, recognition and treatment of mental and substance abuse disorders are among the most promising approaches to suicide prevention. Outcomes of pregnancy and childbirth can be affected by both health and social factors, such as income and access to healthcare (1). Key Findings Birth rates in DuPage County, as well as in Illinois and the United States, have decreased over the past decade. The number of live births have declined at a faster rate in DuPage, with a 22 percent decrease from 2000 to 2013. Racial and ethnic disparities are seen in percentage of mothers who gave birth to a low birth weight infant as well as in percentage of births to adolescents. The percentage of mothers who reported breastfeeding at discharge from the hospital after delivery is lower for black mothers, mothers with a high school diploma or less education, unmarried mothers, and mothers under age twenty-four. DuPage County Birth Trends DuPage County Live Births by Year, 2000-2013 16,000 14,000 12,000 Number of Births 10,000 8,000 6,000 4,000 2,000 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012* 2013* Births 13,528 13,393 12,811 12,894 12,613 12,376 11,868 11,640 11,312 10,820 10,783 10,767 10,525 10,573 Year Graph 8. The decreasing number of births in DuPage County is similar to state and national trends, as seen in Table 8. However, since that time, the DuPage County birth rate has steadily declined while the Illinois and U. During this same time period, the infant mortality rate in DuPage County has consistently remained below the infant mortality rate for Illinois, but has been higher than the infant mortality rate for the United States in 2001, 2005, and 2006 (2,9). The infant mortality rate for black infants was higher than white, Asian, or Hispanic infants in 2007 and 2010. However, some mothers may be unable to access needed prenatal care as a result of not knowing they are pregnant or lack of health insurance coverage or transportation (10). Women who are married and have some level of college education were also more likely to receive prenatal care in the first trimester. With regard to race and ethnicity, white and non-Hispanic or Latino mothers had higher percentages of prenatal care in the first trimester. The categories are defined as follows: inadequate care: prenatal care begun after the 4th month or under 50% of expected visits were received; intermediate care: prenatal care begun by the 4th month and 50-79% of expected visits were received; adequate care: prenatal care begun by the 4th month and 80-109% of expected visits were received; adequate plus (intensive) care: prenatal care begun by the 4th month and 110% of expected visits were received (11). Risk factors for low birth weight include premature birth, chronic health conditions in the mother, birth defects, infections, and tobacco, 16-1c. Infants that are born with low birth weight may be at greater alcohol, risk of chronic conditions later, such as diabetes, heart disease, high blood pressure, and obesity (13). The prevalence of very low birth weight births remained relatively constant over that time period, and the prevalence of 102 moderately low birth weight increased from 5. Prevalence of Low, Moderately Low, and Very Low Birth Weight, DuPage County, 2000-2011 8 7 6. According to the Illinois Pregnancy Risk Assessment Monitoring System, nine percent of Illinois women surveyed in 2010 reported often or always feeling down, depressed, or sad, and nine percent were also told by a health care professional that they had depression (15). In a 2009-2010 survey of a 30-state area, mothers with at least 16 years of education were less likely to report postpartum depressive symptoms than mothers of other levels of education (14). Adolescent mothers are less likely to it is a complete high school, and children of adolescent mothers have higher rates of incarceration (16). Birth rates for adolescents fell 6 percent in the United States between 2011 and 2012 (16). Percent of Live Births to Teens (19 Years and Under) DuPage County and Illinois, 2000-2011 12 11. The majority of babies born to teens were born to white mothers and Hispanic or Latino mothers (5). There was a higher prevalence of moderately low birth weight babies born to teens aged seventeen and younger, 7. Babies born prematurely are at a higher risk for issues such as low birth weight, respiratory problems, and retinopathy (13).

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Multiresistant Pseudomonas aeruginosa outbreak in a pediatric oncology ward related to bath toys. Recommendations for preventing transmission of human immunodeficiency virus and hepatitis B virus to patients during exposure-prone invasive procedures. Management of healthcare workers infected with hepatitis B virus, hepatitis C virus, human immunodeficiency virus, or other bloodborne pathogens. Infection Control Guidance for the Prevention and Control of Influenza in Acute-Care Facilities. Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Updated clinical practice guidelines for the prevention and treatment of mucositis. Current practices in the oral management of the patient undergoing chemotherapy or bone marrow transplantation. American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma. Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma. Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment. Bloodstream infection associated with needleless device use and the importance of infection-control practices in the home health care setting. Nosocomial outbreak of Legionella pneumophila serogroup 3 pneumonia in a new bone marrow transplant unit: evaluation, treatment and control. An outbreak of Legionella micdadei pneumonia in transplant patients: evaluation, molecular epidemiology, and control. Role of environmental surveillance in determining the risk of hospital-acquired legionellosis: a national surveillance study with clinical correlations. Policy for Methicillin-resistant Staphylococcus aureus;The Lancet Infectious Diseases, 2005;5(10): 653-663. Healthcare Infection Control Practices Advisory Committee, Management of Multidrug-Resistant Organisms In Healthcare Settings, 2006. Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia. Selective use of intranasal mupirocin and chlorhexidine bathing and the incidence of methicillinresistant Staphylococcus aureus colonization and infection among intensive care unit patients. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant. Outbreak of mupirocin-resistant Staphylococci in a hospital in Warsaw, Poland, due to plasmid transmission and clonal spread of several strains. The prevalence of low- and high-level mupirocin resistance in staphylococci from 19 European hospitals. Control of an outbreak of an epidemic methicillin-resistant Staphylococcus aureus also resistant to mupirocin. The spread of a mupirocin-resistant/methicillin-resistant Staphylococcus aureus clone in Kuwait hospitals. Molecular characterization and transfer among Staphylococcus strains of a plasmid conferring high-level resistance to mupirocin. Update: Staphylococcus aureus with reduced susceptibility to vancomycin-United States, 1997. Interim guidelines for prevention and control of Staphylococcal infection associated with reduced susceptibility to vancomycin. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional 1224 M.